Description
Semaglutide is an antidiabetic medication used for the treatment of type 2 diabetes and an anti-obesity medication used for long-term weight management.
Semaglutide is a glucagon-like peptide-1 receptor agonist.
By mimicking the action of the incretin glucagon-like peptide-1 (GLP-1), it increases the production of insulin, the hormone that lowers the blood sugar level.
It also appears to enhance growth of pancreatic beta cells, which are responsible for insulin production and release. Additionally, it inhibits the production of glucagon, the hormone that increases glycogenolysis (release of stored carbohydrate from the liver) and gluconeogenesis (synthesis of new glucose).
It reduces food intake by lowering appetite and slowing down digestion in the stomach, helping reduce body fat.
Recommended Dosages
Start Semaglutide with a 0.25 mg subcutaneous injection (injection under the skin) once weekly for 4 weeks.
The 0.25 mg dosage is intended for treatment initiation and is not effective for glycemic control.
After 4 weeks on the 0.25mg dosage, increase the dosage to 0.5mg once weekly.
If additional glycemic control is needed after at least 4 weeks on the 0.5mg dosage, the dosage may be increased to 1mg once weekly.
If additional glycemic control is needed after at least 4 weeks on the 1mg dosage, the dosage may be increased to 2mg once weekly.
The maximum recommended dosage is 2mg once weekly.
Administering Semaglutide
Administer Semaglutide, once weekly, on the same day each week, at any time of the day, with or without meals.
The day of weekly administration can be changed if necessary as long as the time between two doses is at least 2 days (>48 hours).
If a dose is missed, administer Semaglutide as soon as possible within 5 days after the missed dose. If more than 5 days have passed, skip the missed dose and administer the next dose on the regularly scheduled day. In each case, patients can then resume their regular once weekly dosing schedule
NOTE
Semaglutide is not for use in people with type 1 diabetes.
Possible side effects;
- Nausea
- Diarrhea
- Vomiting
- Constipation
- Abdominal pain
- Headache
- Fatigue
- Indigestion/heartburn
- Dizziness
- Hypoglycemia (low blood glucose) in patients with type 2 diabetes
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